Basic Information
Name: 3-Bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxylic acid
Molecular formula: C₉H₅BrClN₃O₂
Molecular weight: 302.51
CAS number: 500011-86-9
2.Physical and Chemical Properties
- Appearance: White to off-white crystalline powder
- Melting point: Approximately 200–210 °C
- Solubility: Slightly soluble in water; soluble in methanol, ethanol, DMF, DMSO and ethyl acetate
- Stability: Stable; store sealed, protected from light
3.Main Functions and Applications (What are its uses?)
Pesticide intermediate (core application): Key intermediate for the synthesis of chlorantraniliprole, a ryanodine- receptor activator insecticide with broad-spectrum activity, highly effective against lepidopteran pests.
Agrochemical synthesis: Building block for diamide-class insecticides.
Fine chemical intermediate: Bromine- and chlorine-containing heterocyclic carboxylic acid used in further fine chemical and pharmaceutical synthesis.
4.A Benchmark-Level Industrial Masterpiece - A Meticulously Crafted "Agrochemical-Grade" Cornerstone Intermediate!
Purity ≥ 99.0%.
Low moisture, residue on ignition and heavy metals. Consistent quality for downstream insecticide synthesis.
"What you see is what you get" - every lot ships with a complete certificate of analysis.
Chromatography Analysis - 3-Bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxylic acid
Signal: VWD1 A, Wavelength = 254 nm (C18 column, 4.6 mm × 250 mm × 5 μm; acetonitrile-water gradient; 1.0 mL/min)
|
Retention Time (min) |
Type |
Peak Width (min) |
Peak Area |
Peak Height |
Area% |
|
4.218 |
MM |
0.102 |
4.5 |
0.5 |
0.03 |
|
6.806 |
MM |
0.128 |
7.6 |
0.9 |
0.05 |
|
8.424 |
MM |
0.144 |
13.6 |
1.5 |
0.09 |
|
10.218 |
MM |
0.160 |
15000.0 |
1820.4 |
99.00 |
|
12.602 |
MM |
0.156 |
33.3 |
3.8 |
0.22 |
|
14.818 |
MM |
0.170 |
28.8 |
3.3 |
0.19 |
|
16.406 |
MM |
0.184 |
22.7 |
2.6 |
0.15 |
|
18.214 |
MM |
0.198 |
18.2 |
2.1 |
0.12 |
|
20.002 |
MM |
0.210 |
13.6 |
1.6 |
0.09 |
|
21.806 |
MM |
0.224 |
9.1 |
1.1 |
0.06 |
- Determination method: Karl Fischer titration (standard: ≤ 0.5%) Moisture content 0.18%
- Test method: Residue on ignition method (specification limit: ≤ 0.1%) Residue on ignition 0.03%
- Test method: Capillary melting point method (quality standard: 200–210 °C) Melting point 205.3 °C
Product Specification - 3-Bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5- carboxylic acid
|
Item |
Specification |
|
Product model |
3-Bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5- carboxylic acid |
|
Appearance |
White to off-white crystalline powder |
|
Purity (HPLC, %) |
≥ 99.0 |
|
Melting point (°C) |
200 – 210 |
|
Water content (%, K.F.) |
≤ 0.5 |
|
Loss on drying (%) |
≤ 0.5 |
|
Residue on ignition (%) |
≤ 0.1 |
|
Heavy metals (ppm) |
≤ 20 |
|
Packaging |
25 kg fiber drum / 1 kg aluminum foil bag |
- Test methods reference: purity and related substances by HPLC (area normalization); water by Karl Fischer titration (GB/T 6283); melting range by capillary method (GB/T 617); residue on ignition (GB/T 7531); heavy metals by colorimetric method.
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